A new frontier in autoimmune disease treatment
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Clinical trials are currently testing the innovative use of CAR T-cell therapy, typically used for cancer treatment, for the treatment of autoimmune diseases. This research seeks to leverage the therapy's ability to modify the immune system, potentially offering new hope to patients with conditions like lupus and multiple sclerosis. By reprogramming T-cells to target the immune responses responsible for autoimmune pathology, researchers are hopeful that this approach could provide substantial relief and perhaps even sustained remission in diseases that are challenging to control with current therapies. Future results from these controlled trials could be revolutionary for the application of CAR T-cell therapy.
Source
Müller, F., Taubmann, J., Bucci, L., Wilhelm, A., Bergmann, C., Völkl, S., Aigner, M., Rothe, T., Minopoulou, I., Tur, C., Knitza, J., Kharboutli, S., Kretschmann, S., Vasova, I., Spoerl, S., Reimann, H., Munoz, L., Gerlach, R. G., Schäfer, S., Grieshaber-Bouyer, R., … Schett, G. (2024). CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. The New England journal of medicine, 390(8), 687–700. https://doi.org/10.1056/NEJMoa2308917
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